顎下リンパ節の腫脹を契機に診断に至った血管免疫芽球性T細胞リンパ腫の1例

• Published in: 日本口腔外科学会雑誌 Vol. 65; no. 4; pp. 257 - 262
• Main Authors: 鵜澤, 成一, 末松, 基生, 松宮, 由香, 竹下, 彰範, 今井, 智章, 宇佐美, 悠
• Format: Journal Article
• Language: Japanese
• Published: 社団法人 日本口腔外科学会 20.04.2019
• Subjects: 血管免疫芽球性Ｔ細胞リンパ腫; 顎下リンパ節
• ISSN: 0021-5163; 2186-1579
• DOI: 10.5794/jjoms.65.257

Angioimmunoblastic T-cell lymphoma (AITL) is one of the subtypes of non-Hodgkin lymphoma. The neoplasm is characterized by aggressive, rapid growth and a poor prognosis. A standard treatment protocol has not been established. In our literature review, only one case of AITL of the head and neck was diagnosed. We report a case of AITL diagnosed by submandibular lymph node biopsy. A 74-year-old woman visited our department because of a swelling in submandibular region. Magnetic resonance imaging showed multiple lymphadenopathy in the bilateral submandibular region. Positron-emission tomography-computed tomography showed the abnormal uptake of FDG in lymph nodes of the entire body. A submandibular lymph node biopsy was performed, and AITL was diagnosed histopathologically. CHOP or Hyper-CVAD, which are standard treatments for non-Hodgkin lymphoma, were proposed, but were not accepted by the patient. Alternatively, anti-CCR4 antibody therapy was conducted, but resulted in poor control of the disease. Finally, palliative care was performed until the patient died of the disease.