上顎歯肉に発生した非AIDS関連カポジ肉腫の1例

• Published in: 日本口腔外科学会雑誌 Vol. 64; no. 4; pp. 219 - 224
• Main Authors: 小川, 千晴, 大山, 定男, 内田, 育宏, 吉田, 俊一, 莇生田, 整治, 船田, 信顕
• Format: Journal Article
• Language: Japanese
• Published: 社団法人 日本口腔外科学会 20.04.2018
• Subjects: カポジ肉腫; ヒトヘルペスウィルス8; 特発性CD4陽性Tリンパ球減少症; 非AIDS関連
• ISSN: 0021-5163; 2186-1579
• DOI: 10.5794/jjoms.64.219

Kaposi's sarcoma (KS) is commonly regarded as an acquired immunodeficiency syndrome (AIDS)-related malignancy. It is caused by human herpesvirus 8 (HHV-8), and sexual intercourse between homosexual men is also considered to be greatly involved.　However, KS rarely develops from HHV-8 infection alone and is thought to arise from an opportunistic infection resulting from immunodeficiency, particularly human acquired immunodeficiency virus (HIV). Here, we report a case of non-AIDS-related KS of the maxillary gingiva. A 60-year-old man was given a diagnosis of KS, which was confirmed by biopsy. He presented with a painless swelling that had an unclear dark purple border from the left upper maxillary first molar to the wisdom tooth. HHV-8 infection and a reduction in CD4+ T lymphocytes were observed, but HIV was negative. Idiopathic CD4+ T lymphocytopenia was presumed to be the cause of the reduction in CD4+ T lymphocytes. Radiotherapy was performed for KS of the maxillary gingiva, and the lesion disappeared. The patient received treatment 12 years ago and currently remains free of recurrence.