VenlafaxineおよびO-desmethylvenlafaxineにおける鏡像異性体の薬物動態学的解析

• Published in: 日本薬理学会年会要旨集 p. 2-O-037
• Main Authors: 加藤, 和子, 佐々木, 太郎, 佐々木, はづき, 井上, 義政, 黒田, 仁一, 下田, 和孝, 渡邊, 崇, 古郡, 規雄, 篠﨑, 將貴, 林, 有希
• Format: Journal Article
• Language: Japanese
• Published: 公益社団法人 日本薬理学会 2020
• Subjects: antidepressant; cytochrome P-450; pharmacogenetics; pharmacokinetics
• ISSN: 2435-4953
• DOI: 10.1254/jpssuppl.93.0_2-O-037

Introduction Venlafaxine (VEN) has been used in many countries since 1993, however, VEN was introduced to clinical setting in 2015 in Japan and pharmacokinetic data of VEN in Japanese has not been so much accumulated. VEN is available as a racemic mixture of S-(+)-VEN and R-(-)-VEN, and these enantiomers have different pharmacological properties. Patients and Methods Subjects were 41 Japanese patients treated with racemic VEN more than 1 week. Steady-state plasma concentrations of VEN, ODV, S-VEN, R-VEN, S-ODV and R-ODV were measured using the high-performance liquid chromatography. Spearman rank correlation tests were used. Results Positive and significant correlations were found between the daily dose of VEN corrected for body weight and the steady-state plasma concentrations of VEN, ODV, S-VEN, R-VEN, S-ODV and R-ODV, respectively (P<0.05). An R-ODV/R-VEN was significantly higher than S-ODV/S-VEN (p<0.05). Conclusion The plasma concentrations of VEN, ODV, S-VEN, R-VEN, S-ODV and R-ODV were positively correlated with the daily dose of VEN. R-desmethylation of VEN showed enantioselectivity over S- desmethylation of VEN.