オリゴデンドロサイトおよびオリゴデンドロサイト前駆細胞は血液脳関門機能を亢進する

• Published in: 日本薬理学会年会要旨集 p. 3-P-017
• Main Authors: 木村, 郁哉, 道具, 伸也, 高田, 芙友子, 松本, 純一, 片岡, 泰文, 山内, 淳史
• Format: Journal Article
• Language: Japanese
• Published: 公益社団法人 日本薬理学会 2019
• ISSN: 2435-4953
• DOI: 10.1254/jpssuppl.92.0_3-P-017

The blood-brain barrier (BBB) is an essential property of cerebrovasculature for maintaining the highly specialized brain microenvironment. Recent studies suggest that an interaction between brain endothelial cells (BECs) and their neighboring cells is required for BBB function. Here, we presented the oligodendrocytes and oligodendrocyte progenitor cells (OPCs) as a positive regulator of BBB integrity. We found that the treatment of AG1296 (PDGFRα inhibitor) attenuated the facilitatory effects of OPCs on BBB function, suggesting that OPCs upregulate BBB integrity via PDGF-BB/PDGFRα pathway between BECs and OPCs. On the other hand, an inhibition of PDGFRα failed to affect the oligodendrocyte-induced BBB upregulation, suggesting that oligodendrocytes enhance BBB function through pathways other than PDGF-BB/PDGFRα signaling. Further studies are required for the understanding of the mechanisms underlying BEC-OPC and BEC-oligodendrocyte interactions in regulating BBB integrity.