Hematologic, biochemical, and endocrine effects of dexamethasone on bottlenose dolphins (Tursiops truncatus)

Two Atlantic bottlenose dolphins (Tursiops truncatus) were given 0.11 mg/kg dexamethasone p.o., and complete blood count and serum chemistry analyses, including insulin, thyroxine (T4) adrenocorticotrophic hormone (ACTH), and cortisol level determinations, were performed at 0 hr, 24 hr, 36 hr, 48 hr...

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Bibliographic Details
Published inJournal of zoo and wildlife medicine Vol. 30; no. 2; p. 310
Main Authors Reidarson, T H, McBain, J F
Format Journal Article
LanguageEnglish
Published United States 01.06.1999
Subjects
Administration, Oral
Adrenocorticotropic Hormone - blood
Animals
Appetite - drug effects
Appetite Stimulants - administration & dosage
Appetite Stimulants - pharmacology
Blood Cell Count - drug effects
Blood Cell Count - veterinary
Blood Chemical Analysis - veterinary
Blood Glucose - analysis
Blood Glucose - drug effects
Dexamethasone - administration & dosage
Dexamethasone - pharmacology
Dolphins - blood
Dolphins - metabolism
Glucocorticoids - administration & dosage
Glucocorticoids - pharmacology
Hydrocortisone - blood
Male
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Summary:Two Atlantic bottlenose dolphins (Tursiops truncatus) were given 0.11 mg/kg dexamethasone p.o., and complete blood count and serum chemistry analyses, including insulin, thyroxine (T4) adrenocorticotrophic hormone (ACTH), and cortisol level determinations, were performed at 0 hr, 24 hr, 36 hr, 48 hr, 7 days, and 17 days. Significant changes included neutrophilia, eosinopenia, lymphopenia, elevated insulin, and depressed ACTH and cortisol levels within 24 hr of dexamethasone administration. These effects were rapid, and values returned to normal within 48 hr.
ISSN:1042-7260