上顎骨巨細胞修復性肉芽腫に起因した腫瘍性骨軟化症の1例
Tumor-induced osteomalacia (TIO) is a rare disease associated with bone pain, walk disturbance accompanied by muscular atrophy of limbs, and malnutrition. To our knowledge, only 63 cases of TIO due to maxillofacial tumor have been reported. It is already known that the causative factor, FGF-23, is p...
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Published in | 日本口腔外科学会雑誌 Vol. 65; no. 2; pp. 78 - 82 |
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Main Authors | , , , , |
Format | Journal Article |
Language | Japanese |
Published |
社団法人 日本口腔外科学会
20.02.2019
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Subjects | |
Online Access | Get full text |
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Summary: | Tumor-induced osteomalacia (TIO) is a rare disease associated with bone pain, walk disturbance accompanied by muscular atrophy of limbs, and malnutrition. To our knowledge, only 63 cases of TIO due to maxillofacial tumor have been reported. It is already known that the causative factor, FGF-23, is produced by tumors, resulting in TIO. We describe our experience with a 57-year-old woman who had swelling in the palate and walk disturbance accompanied by severe lower limb pain. Hypophosphatemia and hypocalcemia were detected on blood tests. The histopathological diagnosis of the maxillary granuloma was giant cell reparative granuloma, and partial resection of the maxilla was performed given the possibility of TIO. In the 3 weeks after surgery, pain in the lower extremity and walk disturbance improved markedly. Currently, there is no recurrence as of 3 years after surgery, and the course is good. |
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ISSN: | 0021-5163 2186-1579 |
DOI: | 10.5794/jjoms.65.78 |