C1インヒビター投与下に囊胞摘出術を行った遺伝性血管浮腫の1例

• Published in: 日本口腔外科学会雑誌 Vol. 57; no. 2; pp. 74 - 77
• Main Authors: 濱田, 正和, 新谷, 素子, 今井, 智章, 奥長, 秀介, 青田, 桂子, 由良, 義明
• Format: Journal Article
• Language: Japanese
• Published: 社団法人 日本口腔外科学会 20.02.2011
• Subjects: C1インヒビター; 喉頭浮腫; 遺伝性血管浮腫
• ISSN: 0021-5163; 2186-1579
• DOI: 10.5794/jjoms.57.74

Hereditary angioedema （HAE） causes life-threatening laryngeal edema. The attack can be triggered,in general, by trauma, drugs, and infection. The risk after dental treatment and oral surgery is higher than that after other surgical procedures.We report on a 41-year-old woman with psoriasis arthropica and HAE who required tooth extraction and a cystectomy. To prevent angioedema, we injected tranexamic acid and C1 inhibitor before surgery. She underwent tooth extraction and a cystectomy under intravenous sedation. She was closely monitored during the night and was discharged from the hospital on the 4th day after operation. The patient received surgery successfully without any complications.The use of tranexamic acid, C1 inhibitor, and intravenous sedation is effective for preventing attacks of angioedema in HAE patients.