Trinitrotoluene: a review of reported dose-related effects providing documentation for a workplace standard

The scientific and medical literature on TNT was reviewed with emphasis on studies providing correlation between work exposures and adverse health effects. Numerous adverse effects including upper respiratory and gastrointestinal complaints, anemia, liver function abnormalities, and possibly aplasti...

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Bibliographic Details
Published inJournal of occupational medicine Vol. 19; no. 5; p. 341
Main Author Hathaway, J A
Format Journal Article
LanguageEnglish
Published United States 01.05.1977
Subjects
Anemia, Aplastic - chemically induced
Animals
Blood Cell Count
Blood Cells - drug effects
Cats
Dermatitis, Occupational - etiology
Dogs
Environmental Exposure
Gastrointestinal Diseases - chemically induced
Hemoglobins - metabolism
Humans
Irritants - pharmacology
Liver - drug effects
Occupational Diseases - chemically induced
Rabbits
Rats
Respiratory Tract Diseases - chemically induced
Trinitrotoluene - adverse effects
Trinitrotoluene - pharmacology
Trinitrotoluene - toxicity
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Summary:The scientific and medical literature on TNT was reviewed with emphasis on studies providing correlation between work exposures and adverse health effects. Numerous adverse effects including upper respiratory and gastrointestinal complaints, anemia, liver function abnormalities, and possibly aplastic anemia have been noted at TNT levels below the current standard of 1.5 mg/m3. Mild biological effects, particularly reduction in hemoglobin levels or red blood cell counts, have been noted at exposures as low as 0.2 mg/m3. A workplace standard of 0.5 mg/m3 as an 8 hour time-weighted exposure is suggested for protection against adverse health effects.
ISSN:0096-1736