フッ化カドミウム静脈内単回投与後の急性有害影響(第1報) 致死量・肝障害・腎障害・電解質異常・代謝性アシドーシス

• Published in: BIOMEDICAL RESEARCH ON TRACE ELEMENTS Vol. 18; no. 4; pp. 400 - 404
• Main Authors: 土手, 友太郎, 足立, 和也, 土手, 江美, 三井, 剛, 河野, 公一
• Format: Journal Article
• Language: Japanese
• Published: 日本微量元素学会 2007
• ISSN: 0916-717X; 1880-1404
• DOI: 10.11299/brte.18.400

Cadmium fluoride(CdF2)is commonly used as an insulator for super-high-speed mass telecommunications equipment, and there is a considerable risk that industrial workers will inhale CdF2 particles. Despite the possibility that acute exposure can cause harmful systemic effects, there are no studies to date that address the health consequences of acute CdF2 exposure. This study therefore aimed to determine the acute lethal dose of CdF2 and its effects on various target organs, including the liver and kidney. We also determined the effect of CdF2 on serum electrolytes and acid-base balance. The effective lethal dose was determined and dose-response study was conducted after intravenous administration of CdF2 in rats. The 24h LD50 of CdF2 was determined to be 3.29 mg/kg. The dose-response study used doses of 1.34, 2.67, 4.01 mg/kg CdF2. Saline or sodium fluoride solution were used for controls. Severe hepatocellular injury was induced at doses greater than 2.67 mg/kg, as demonstrated by AST and ALT activities greater than 1,500 IU/L in rats injected with a dose of 4.01 mg/kg. Acute renal failure was induced at doses greater than 2.67 mg/kg. Decreased serum Ca, increased serum K and metabolic acidosis were induced at a dose of 4.01mg/kg. It was suggested that decreased serum Ca was caused by the exposure to ionized F. CdF2 has the strongest lethal and hepatic toxicity among all Cd containing compounds.