BASIC AND CLINICAL STUDIES ON CEFUROXIME AXETIL IN ORAL SURGERY

• Published in: CHEMOTHERAPY Vol. 38; no. 12; pp. 1193 - 1205
• Main Authors: Motoji, Shigeki, Nakao, Kaoru, Nakasuji, Kanako, Kobayashi, Sohichiro, Shimada, Keikichi, Sano, Eisaku, Yoshii, Takashi, Ohtsuka, Yoshiki, Ichii, Masaaki, Hirano, Fuki
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1990; 公益社団法人 日本化学療法学会
• Subjects: Cefuroxime axetil (CXM-AX); Concentration of tooth extraction wound; Oral infection; Transition of oral tissue; セフロキシムアキセチル; 口腔感染症; 口腔組織移行; 抜歯創内濃度
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.38.1193

We carried out basic and clinical studies to evaluate the usefulness of cefuroxime axetil (CXMAX) in dentistry and oral surgery, and obtained the following results. 1. The antibacterial activity of CXM was determined and compared with those of cefaclor (CCL), cefteram (CFTM) and ampicillin (ABPC), against 74 strains clinically isolated at our Department. CMX's activity was slightly superior to those of CCL and CFTM, although inferior to that of ABPC, against Gram-positive organisms (30 strains). Against Gram-negative organisms (44 strains) it was similar to those of CCL and ABPC, but inferior to that of CFTM. 2. The transfer of CXM into oral tissue after administration of 250mg in non-fasting subjects was determind. It transfered equally well into tooth extraction wound and peripheral vein blood. Transfer of CXM into gingiva was comparable or superior to those of the reference antibiotics, the ratio of peak concentrations in gingiva to those in serum being 0.41±0.12. 3. In a clinical evaluation, 12 patients with periodontitis and 2 with ostitis were treated with 750mg or 1, 500mg CXM-AX per day. The efficacy of the treatment was assessed by thedoctors in charge as exellent or good in 10 cases, the efficacy rate being 71.4%. Judged by points efficacy was assessed as excellent or good in 9 cases and the efficacy rate was 64.3%. The only side effect noted was soft stool in one case, but this was mild. 4. We consider CXM-AX to be a safe and useful drug in treating mild or moderate infections in dentistry and oral surgery.