Clinical evaluation of cefminox sodium and investigation of its effects on platelet function and blood coagulation

• Published in: CHEMOTHERAPY Vol. 40; no. 11; pp. 1327 - 1335
• Main Authors: Yamada, Minehiko, Kaneko, Norihiro, Akizawa, Takanori, Nakagami, Kazukyo, Ohtsuka, Hidehiko, Tanaka, Kazumasa, Suzuki, Hajime, Noguchi, Eisei, Terada, Hideo, Narushima, Michiaki
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1992; 公益社団法人 日本化学療法学会
• Subjects: CMNX; 出血傾向; 呼吸器感染症; 血小板機能; 血液凝固機能
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.40.1327

The efficacy of cefminox sodium (CMNX) in the treatment of respiratory tract infection and its effect on platelet function and blood coagulation were investigated. The subjects were 22 patients with respiratory tract infections, 14 with pneumonia, 4 with bronchitis, 3 with pleurisy, and 1 with pulmonary suppuration. CMNX was administered by drip infusion in a dose of 4 g/day. Clinical efficacy in 20 patients with respiratory tract infections was as follows: excellent in 7 cases, moderate in 9 cases, and poor in 4 cases. The over-all efficacy rate was 80%. Bacteriologicvally, a total of 9 strains were eradicated. No objective or subjective side effects of CMNX were detected, although slight transaminase elevation was observed in three patients. The effects of CMNX on platelet function and blood coagulation were investigated, i. e., before administration of CMNX, and again after 7 days of administration the following parameters were measured: platelet count, bleeding time, platelet adhesiveness, platelet aggregation, platelet ATP release activity, prothrombin time, active partial thromboplastin time, serum fibrinogen, fibrin degradation products, thrombo test, hepaplastin test, coagulation factors II, VII, IX, X, and PIVKA-II. The results failed to reveal any effect on platelet function or blood coagulation. Thus it was concluded that CMNX is highly efficacious in the treatment of respiratory tract infection and that it is a safe antibiotic in terns of platelet function and blood coagulation.