CONCENTRATION OF CEFOTETAN IN THE HUMAN LUNG TISSUE AND SERUM, AND ITS CLINICAL EFFICACY

• Published in: CHEMOTHERAPY Vol. 34; no. 10; pp. 988 - 992
• Main Authors: TATSUMURA, TOSHIKI, SUGIYAMA, SHIGEKI, KIMOTO, FUMIHIKO, KOYAMA, SHINJI, AKEMOTO, KATSUSHI, HASHIMOTO, HIDEKI, TSUDA, MOTOHARU, SEKI, MASAHIRO, YAMAMOTO, KEIICHI
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1986
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.34.988

The serially determined concentrations of CTT in human serum after 1g of its intravenous administration revealed very high level of CTT and was persistent in character. They were 155.0μg/ml (30 min.), 114.6μg/ml (60 min.), 112.0μg/ml (90 min.), 93.5μg/ml (120 min.) and 72.0μg/ml (180 min.), respectively. And the concentrations of CTT in the lung tissue were also observed to be high and persistent as comparable to the concentration in the serum noted in the present studies. They were 40.7μg/g (30 min.), 38.7μg/g (60 min.) and 27.9μg/g (120 min.). The clinical study of 7 cases where CTT was used for the prevention of postoperative infection showed very favorable results without causing any postoperative complication to the lung. Besides this, there were 4 other cases CTT was clinically used. In 2 cases of primary lobar pneumonia, good antibacterial effects were obtained with CTT, while one of them did not respond to CTX and GM, but indicated and excellent antibacterial effects of CTT. In the remaining 2 cases of emphysema with mixed infection, fairly good antibacterial response was obtained.