IN VITRO SUSCEPTIBILITY OF JAPANESE ISOLATES OF PENICILLINASE-PRODUCING NEISSERIA GONORRHOEAE TO 38 ANTIMICROBIAL AGENTS

• Published in: CHEMOTHERAPY Vol. 33; no. 3; pp. 199 - 206
• Main Authors: KANEKO, YASUKO, IKEDA, FUMIAKI, NISHIDA, MINORU, GOTO, SACHIKO, YAMAI, SHIRO, OBARA, YASUSHI
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1985; 公益社団法人 日本化学療法学会
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.33.199

A total of 116 isolates of penicillinase-producing Nsisseria gonorrhosas (PPNG) from patients with sexually transmitted diseases in many hospitals, in Japan, were collected in the Kanagawa Prefectural Public Health Laboratory, and tested for their susceptibility to 38 antimicrobial agents.All strains were highly susceptible to 3 rd-generation cephems including cefoperazone, cefotaxime, ceftazidime and FK-027 (a new oral cephem) and new pyridone carboxylic acids such as norfloxacin, oflozacin, enozscin. One of the isolates tested was resistant to these drugs.Although all strains of PPNG tested were highly resistant to amoxicillin, the susceptibility of these strains to this antibiotic was greatly enhanced in the presence of clavulanic acid (augmentin). Furthermore, piperacillin, and erythromycin were also highly active against the strains of PPNG tested. Methicillin, oxacillin and dicloxacillin, unlike PCase-susceptible penicillins, were very stable to β-lactamase from the strains of PPNG used. However, no correlation was found between their stability and antibacterial activity against the strains used.