Influence of Oral Use of Anti-Tuberculous Drugs on Endocrine Milieu: Relationship to Acneiform Eruptions

Serum luteinizing hormone (LH), estrone (E1), estradiol (E2), total testosterone (T), free testosterone (FT), dihydrotestosterone (DHT), and dehydroepiandrosterone sulfate (DHEA-S) levels in 12 male patients with tuberculosis were measured by RIA prior to and after 8 weeks administration of anti-tub...

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Bibliographic Details
Published inSkin research Vol. 34; no. 4; pp. 429 - 432
Main Authors Aizawa, Hiroshi, Morimoto, Teruko, Niimura, Michihito
Format Journal Article
LanguageEnglish
Published Meeting of Osaka Dermatological Association 1992
Subjects
acneiform eruptions
anti-tuberculous drugs
cytochrome p-450
hormone
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Summary:Serum luteinizing hormone (LH), estrone (E1), estradiol (E2), total testosterone (T), free testosterone (FT), dihydrotestosterone (DHT), and dehydroepiandrosterone sulfate (DHEA-S) levels in 12 male patients with tuberculosis were measured by RIA prior to and after 8 weeks administration of anti-tuberculous drugs, to investigate their relationship to acneiform eruptions. There were no significant changes in the levels of serum LH, E1, FT, DHT, or DHEA-S, but a significant increase in the level of T, and a significant decrease in the level of E2 were found. Based on these results, we suspected that the hepatic metabolic enzyme activities dependent on cytochromes p-450 were inhibited, and that aromatase activity in the cutaneous tissue was depressed. This suggests that fluctuations in the serum sex steroid hormone levels are one of the possible bases for the occurrence of an acneiform erupion.
ISSN:0018-1390
1884-541X
DOI:10.11340/skinresearch1959.34.429