Sensitivity of Streptococcus pneumoniae isolated from clinical materials to oral antimicrobial agents

• Published in: CHEMOTHERAPY Vol. 42; no. 5; pp. 592 - 598
• Main Authors: Narita, Hirokazu, Minami, Shinzaburou, Deguchi, Koichi, Maehana, Junko, Kitayama, Rieko, Horii, Taeko, Watanabe, Yasuo, Yasuda, Takashi
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1994; 公益社団法人 日本化学療法学会
• Subjects: 感受性相関; 経口抗菌薬; 肺炎球菌; 薬剤感受性
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.42.592

We investigated the sensitivity of 40 strains of Streptococcus pneumoniae, which were isolated from clinical materials in Japan from 1982 to 1990, to various oral antimicrobial agents. There were 5 benzylpenicillin (PCG)-insensitive strains and no PCG-resistant strains. The MIC80s of cefteram and amoxicillin against the PCG-sensitive strains (35 strains) were the best and were followed by cefroxime, cefpodoxime>cefdinir>cefotiam>tosufloxacin, cefixime>sparfloxacin>levofloxacin, cefaclor>ciprofloxacin, ofloxacin, cephalexin>ceftibuten, minocycline>josamycin, erythromycin and clarithromycin. The MICs of amoxicillin, cefteram, cefroxime, cefpodoxime, cefdinir, cefotiam and tosufloxacin against PCG-insensitive strains (5 strains) were superior to those of other agents. Correlations between MICs of various β-lactams revealed that some strains became insensitive especially to cephems having an oxyimino or a 2-carboxyethylidene group on the 7-acyl side-chain.