Adverse effects of antimicrobial agents The mechanisms of their concentration-dependent effects

Recently many antimicrobial agents are used for treatment of infectious diseases.These agents are known to potentially have adverse effects.The adverse effects of antimicrobial agents are classified to two major groups; 1) concentration-independent effects and 2) concentration-dependent effects.Larg...

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Bibliographic Details
Published inJapanese Journal of Chemotherapy Vol. 52; no. 6; pp. 293 - 303
Main Author Hori, Seiji
Format Journal Article
LanguageJapanese
Published Japanese Society of Chemotherapy 2004
公益社団法人 日本化学療法学会
Subjects
adverse effect
antimicrobial agents
mechanism
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ISSN1340-7007
1884-5886
DOI10.11250/chemotherapy1995.52.293

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Summary:Recently many antimicrobial agents are used for treatment of infectious diseases.These agents are known to potentially have adverse effects.The adverse effects of antimicrobial agents are classified to two major groups; 1) concentration-independent effects and 2) concentration-dependent effects.Large part of the mechanism of these adverse effects remains unclear.In this paper, we will discuss the mechanisms of aminoglucoside-and glycopeptide-induced nephropathy, aminoglycoside-induced ototoxicity, β-lactam-and quinolone-induced convulsions, cephem-induced bleeding tendency and antabuse-like effect, and quinolone-induced hypeglycemia.
ISSN:1340-7007
1884-5886
DOI:10.11250/chemotherapy1995.52.293