Regulatory effect of m6A modification on different viruses

N6‐methyladenosine (m6A) modification is the most common and reversible posttranscriptional modification of RNA in eukaryotes, which is mainly regulated by methyltransferase, demethylase, and specific binding protein. The replication of the virus and host immune response to the virus are affected by...

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Bibliographic Details
Published inJournal of medical virology Vol. 93; no. 11; pp. 6100 - 6115
Main Authors Yu, Pei‐Lun, Cao, San‐Jie, Wu, Rui, Zhao, Qin, Yan, Qi‐Gui
Format Journal Article
LanguageEnglish
Published London Wiley Subscription Services, Inc 01.11.2021
Subjects
Eukaryotes
Immune response
Methyltransferase
N6-methyladenosine
N6‐methyladenosine (m6A)
Post-transcription
regulatory effect
RNA modification
Virology
virus
Viruses
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Summary:N6‐methyladenosine (m6A) modification is the most common and reversible posttranscriptional modification of RNA in eukaryotes, which is mainly regulated by methyltransferase, demethylase, and specific binding protein. The replication of the virus and host immune response to the virus are affected by m6A modification. In different kinds of viruses, m6A modification has two completely opposite regulatory functions. This paper reviews the regulatory effects of m6A modification on different viruses and provides a reference for studying the regulatory effects of RNA epitranscriptomic modification.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.27246