ANTIBIOTICS FROM BASIDIOMYCETES XXXI. ALEURODISCAL: AN ANTIFUNGAL SESTERTERPENOID FROM ALEURODISCUS MIRABILIS (BERK. & CURT.) HÖHN

• Published in: Journal of antibiotics Vol. 42; no. 6; pp. 875 - 882
• Main Authors: LAUER, URSULA, ANKE, TIMM, SHELDRICK, WILLIAM S., SCHERER, ANGELA, STEGLICH, WOLFGANG
• Format: Journal Article
• Language: English
• Published: Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 01.06.1989; Japan Antibiotics Research Association
• Subjects: Aminoglycosides; Anti-Bacterial Agents - analysis; Anti-Bacterial Agents - biosynthesis; Anti-Bacterial Agents - pharmacology; Antibiotics (antibacterial agents, antifungal agents); Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Antifungal Agents - analysis; Antifungal Agents - biosynthesis; Antifungal Agents - pharmacology; Applied microbiology; Basidiomycota - metabolism; Biological and medical sciences; Chromatography, High Pressure Liquid; Fermentation; Fundamental and applied biological sciences. Psychology; Immunodiffusion; Microbiology; Molecular Structure; Mucor - drug effects; X-Ray Diffraction; Terpenoid; Antibiotic; Antifungal agent; Chemical structure; Cytotoxicity; Activity spectrum; In vitro; Biological activity
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.42.875

Aleurodiscal, an antifungal antibiotic has been isolated from mycelial cultures of Aleurodiscus mirabilis (Berk. & Curt.) Höhn. It causes abnormal apical branchings of Mucor miehei hyphae at very low concentrations. The structure and absolute configuration of the antibiotic has been determined by a single crystal X-ray analysis and hydrolysis to D-(+)-xylose. Aleurodiscal is a hydroxysesterterpene aldehyde β-D-xyloside with a novel carbon skeleton.