THE TOXICITY OF N, N-DIMETHYLFORMAMIDE (DMF)

Industrial use of N, N-dimethylformamide (DMF) is increasing in recent years. The toxic properties of this substance are reviewed from the standpoint of industrial hygiene. Hepatotoxicity has been emphasized by many authors. Care should be taken against the skin absorption of DMF. N-methylformamide...

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Bibliographic Details
Published inSangyo Igaku Vol. 24; no. 1; pp. 3 - 12
Main Authors TANAKA, Ken-ichi, UTSUNOMIYA, Tadao
Format Journal Article
LanguageJapanese
Published Japan Japan Society for Occupational Health 1982
Subjects
Abnormalities, Drug-Induced - etiology
Alcohol Drinking
Animals
Cats
Dimethylformamide - metabolism
Dimethylformamide - toxicity
Dogs
Drug Interactions
Environmental Exposure
Ethanol - toxicity
Guinea Pigs
Humans
Irritants
Lethal Dose 50
Mice
Neoplasms - chemically induced
Occupational Diseases - chemically induced
Rabbits
Rats
Skin - metabolism
Skin Absorption
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Summary:Industrial use of N, N-dimethylformamide (DMF) is increasing in recent years. The toxic properties of this substance are reviewed from the standpoint of industrial hygiene. Hepatotoxicity has been emphasized by many authors. Care should be taken against the skin absorption of DMF. N-methylformamide (MF) was identified as the major urinary metabolite of DMF. Measurements of MF in urine have been found effective as a means of biological monitoring of DMF exposure.
ISSN:0047-1879
1881-1302
DOI:10.1539/joh1959.24.3