Utility of the activity of small intestine type-ALP as a marker for diagnostic criteria in liver diseases

• Published in: Japanese Journal of Clinical Chemistry Vol. 35; no. 3; pp. 273 - 279
• Main Authors: Kariyone, Kazuko, Ito, Hiromi, Hayashi, Seishu, Kato, Masahiko, Takagasa, Nobuyuki, Saito, Junichi, Sobue, Huyuki
• Format: Journal Article
• Language: Japanese
• Published: Japan Society of Clinical Chemistry 2006; 一般社団法人 日本臨床化学会
• Subjects: L-Phe; L-phenylalanine; liver diseases group; selective inhibition assay using; small intestine-type alkaline phosphatase; the ratio of small intestine ALP against γ-GT; 小腸型ALP; 小腸型ALP/γ-GT比; 肝疾患分類; 選択的阻害法
• ISSN: 0370-5633; 2187-4077
• DOI: 10.14921/jscc1971b.35.3_273

We studied the utility of small intestine-type ALP (SI-ALP) activity, which was measured based on an inhibition assay using L-phenylalanine, as one of the markers for diagnostic criteria in liver diseases in comparison with other markers. Chronic liver diseases were divided into the following 4 groups: group L light liver fibrosis (fatty liver, alcoholic liver diseases, etc.). group 2: chronic hepatitis (hepatitis B, C, and nonB, nonC), group 3: liver cirrhosis including liver-cell carcinoma complications and group 4: other particular chronic liver diseases (PBC, IPH, NASH, etc.). Although many markers were found to discriminate between group 2 and 3 using a nonparametric multiple comparison test, the markers to distinguish between group 1 and 2 were only the SI-ALP (P<0.05) and the ratio of SI-ALP against γ-GT (P<0.005). In addition, the ROC analysis for discrimination between group 1 and 2 showed that the most efficient discrimination was achieved by taking the ratio of SI-ALP against γ-GT, followed by γ-GT and SI-ALP. Thus, the SI-ALP is a useful marker for diagnostic criteria on the occurrence of fibrosis in liver disease, and the diagnostic criteria are certainly improved by taking its ratio to γ-GT.