Pharmacokinetics of Cyclosporin in Renal Transplantation Patients

• Published in: Japanese Journal of National Medical Services Vol. 43; no. 5; pp. 555 - 560
• Main Authors: KOTAKE, Takeshi, UETA, Toshihiro, MIHAIZA, Masakazu, INA, Hidekazu, ARAKAWA, Masami, AMEMIYA, Hiroshi, SUZUKI, Seiichi, SAKAKIBARA, Izumi
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of National Medical Services 1989
• ISSN: 0021-1699; 1884-8729
• DOI: 10.11261/iryo1946.43.555

It has been demonstrated that the immunosuppressive therapy is clinically indispensable for organ transplantation. Based on various parameters, we studied pharmacokinetics of cyclosporin in 15 renal transplantation patients. We initially measured the drug concentration by RIA method but we recognized the values in RIA method to be unreliable, and so we measured the drug concentration by HPLC as a preferable method. Almost all cases were taking mizoribine in combination with cyclosporin in which decreased the side effects by reducing doses of cyclosporin. There were eight cases who have been kept in good control on cyclosporin trough level of under 30ng/ml. Doses of cyclosporin should be the reflection of the clearance and the time after the renal transplantation. In the future, such variables as absorption, renal and liver function, time after renal transplantation and individual disparity in AUC should be taken into consideration.