HEMOSTATIC CHANGES AFTER ARTIFICIAL VALVE REPLACEMENT AND ANTI-COAGULANT THERAPY

• Published in: Jinko Zoki Vol. 19; no. 1; pp. 366 - 369
• Main Authors: WATANABE, M., IWAYA, F., ABE, T., SATOKAWA, H., HAGIWARA, K., TANJI, M., Midorikawa, H., TAKASE, S., HOSHINO, S., TSUDA, A., TSUGUO, I., Sato, Y.
• Format: Journal Article
• Language: Japanese
• Published: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS 1990; 一般社団法人 日本人工臓器学会
• Subjects: anti-coagulant therapy; disseminated intravascular coagulation; valve replacement
• ISSN: 0300-0818; 1883-6097
• DOI: 10.11392/jsao1972.19.366

We studied hemostatic changes concerning to disseminated intravascular coagulation (DIC) and postoperative anti-coagulant thrapy in 80 patients after artificial valve replacement. They were divided in 3 groups, such as single valve replacement (S-group), double valve replacement without tricuspid valve regurgitation (D-group) and combined valvular disease with tricuspid valve regurgitation (TR-group). The incidence of tromboembolism were 1.8%/pt-yr in S-group, 4.8%/pt-yr in D-group and 1.2%/pt-yr in TR group. The 5-year % free from thromboembolism were 82.3%, 77.9% and 87.5% respectivily. Preoperative prothombin time (PT) and thrombotest (TT) in TR-group were lower than other groups and were subject to DIC (21%). In D-group, anti-coagulant therapy tended to later after surgery and TT was higher at 3rd-7th operative day. Under anti-coagulant terapy DIC scores were improved by administration of mesilate gabexate.The anti-coagulant therapy was needed after artificial valve replacement as soon as possble.