SELECTIVE ADSORBENT OF EDA (+) FIBRONECTIN

• Published in: Jinko Zoki Vol. 28; no. 1; pp. 118 - 122
• Main Authors: Tamaki, Tohru, Konoeda, Yoshiki, Sakashita, Eiji, Kawamura, Akio, Meguro, Jun-ichi, Tanaka, Mitsuko, Kukita, Kazutaka, Yonekawa, Motoki
• Format: Journal Article
• Language: Japanese
• Published: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS 01.01.1999; 一般社団法人 日本人工臓器学会
• Subjects: adsorption; apheresis; AT III; EDA (+) fibronectin
• ISSN: 0300-0818; 1883-6097
• DOI: 10.11392/jsao1972.28.118

One of the important purposes of apheresis in immune diseases is to remove EDA (+) fibronectin, which becomes elevated in the plasma of patients with serious rheumatoid arthritis, SLE, and rejection of kidney graft. We developed EDA (+) fibronectin adsorbent (OHC-10), but as described previously, it adsorbed not only EDA (+) fibronectin but also AT III and lipids. We recently developed a new adsorbent (OHC-20) which dose not adsorb AT III. Using 1 ml of OHC-20, a single pass test of 40ml blood was performed in 3 volunteers. Reduction rates were calculated for EDA (+) fibronectin, AT III, fibrinogen, cholesterol, triglyceride, and platelets. The reduction rate of EDA (+) fibronectin was more than 40%. One ml of OHC-20 could adsorb EDA (+) fibronectin in more than 40ml of blood. The reduction rate of AT III was less than 10%. Cholesterol and triglyceride were adsorbed to only a small degree. OHC-20 might be practical for the reduction of EDA (+) fibronectin.