The antithrombogenic effect of preoperative administration of small dose of ticlopidine in open-heart surgery

• Published in: Jinko Zoki Vol. 18; no. 2; pp. 920 - 923
• Main Authors: KAMADA, S., KAMADA, T., HOSON, M., ABE, H., MIEDA, T., FUNAKI, S., OKADA, T., HIEKATA, T., YAMATE, N.
• Format: Journal Article
• Language: Japanese
• Published: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS 1989
• Subjects: Open-heart surgery; PF4; platelet; ticlopidine; βTG
• ISSN: 0300-0818; 1883-6097
• DOI: 10.11392/jsao1972.18.920

we analyzed the serial levels of plasma β TG and PE 4 and platelet aggregation to evaluate the preventive effect of proeperative small dose of ticlopidine on the postoperative thrombosis in 41 patients who underwent open heart surgery. The patients were divided into 3 groups: Group I; control (12 cases), Group II; 200mg/day of ticlopidine was started to be administered 2 to 3 days after operation (19 cases), Group III; the same dose of ticlopidine was administered for 7 days preoperatively and readmini stered 2 to 3 days afer operation (10 cases). In Group II, the release of PF 4 was not inhibited during the first 7 postoperative days probably because of the insufficient suppression of platelet aggregation immediately after operation. In Group III, platelet aggregation was consistently maintained in low level during perioperative periods and the incidence of the accentuarion of the release reaction of βTG and PF 4 was reduced as well. It is concluded that the preoperative treatment by 200mg/day of ticlopidine is expected to be effective to prevent the thromboembol is complications immediately after operation without the increased risk of excessive blood loss.