SUSTAINED ETHIONINE AND LIPOPOLYSACCHARIDE FOR PREPARATION OF SIRS MODEL ANIMALS

Ethionine and Lipopolysaccharide were cast into implantable tablet form DDS by photo-polymerization of acrylate. In vitro release rates of drugs were variable with the change of polymer composition and drug concentration. The samples were embedded into rats for the efficient preparation of disease m...

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Bibliographic Details
Published inJinko Zoki Vol. 26; no. 2; pp. 534 - 538
Main Authors KAETSU, I., UCHIDA, K., SHIOMI, T., MIYAMOTO, M., HOKI, M., OHYANAGI, H., SUTANI, K.
Format Journal Article
LanguageJapanese
Published JAPANESE SOCIETY FOR ARTIFICIAL ORGANS 1997
Subjects
Disease model animal
Drug delivery system
Pancreatitis
Polyacrylate
Sepsis
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Summary:Ethionine and Lipopolysaccharide were cast into implantable tablet form DDS by photo-polymerization of acrylate. In vitro release rates of drugs were variable with the change of polymer composition and drug concentration. The samples were embedded into rats for the efficient preparation of disease model animals. After one month the ethionine DDS embedded rat showed an inflammation and a remarkable increase of α-amylase amount in the serum. The lipopolysaccharide DDS embedded rat showed the increase of body temperature and also the TNF concentration in the serum immediately after implantation. The TNF amount had two maxima peaks with the time course. The facts support the two stage attack theory of SIRS by cytokine increases.
ISSN:0300-0818
1883-6097
DOI:10.11392/jsao1972.26.534