EX VIVO EVALUATION OF A NEW ANTITHROMBOGENIC COATING MATERIAL FLUORINE-ACRYL-STYRENE-URETHANE-SILICONE(FASUS) COPOLYMER

• Published in: Jinko Zoki Vol. 23; no. 3; pp. 712 - 716
• Main Authors: KAWAHITO, K, INO, T, ADACHI, H, IDE, H, MIZUHARA, A, YAMAGUCHI, A, MURATA, S.
• Format: Journal Article
• Language: Japanese
• Published: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS 1994
• Subjects: A-V shunt; antithrombogenicity; material; polymer
• ISSN: 0300-0818; 1883-6097
• DOI: 10.11392/jsao1972.23.712

FASUS copolymer is a newly synthesized antithrombotic material, the theoretical basis of which is attributed to its hydrophilic and hydrophobic microdomain structure. In this series of experiments, the blood compatibility of this polymer was evaluated by utilizing the methods of arterio-venous(A-V) shunt in rabbits. Small diameter polyvinyl chloride tubes(3.0mm I. D. and 60cm length) coated by FASUS on their internal surfaces(FASUS, n=5), and without coating(CONTROL, n=5) were implanted in rabbits as A-V shunts. Their differences were assessed by measuring for circulating platelet counts, platelet aggregability, APTT and PT. As a results, FASUS effectively suppressed the decrease in platelets counts and improved pro-longed APTT, there was no difference in PT and platelet aggregabiiity. In conclusion, FASUS showed promising blood compatibility by suppressing the activation of platelets and intrinsic factors.