Concentration of hydroxylated polychlorinated biphenyls (OH-PCBs) in the blood of Yusho patients in 2010

Hydroxylated polychlorinated biphenyls (OH-PCBs) are formed as major metabolites of PCBs by cytochrome P450 enzyme-mediated oxidation. It has been reported that their total concentration in serum samples of Yusho patients ranged from 390 to 1300 pg/g. We measured the concentration of OH-PCBs in bloo...

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Bibliographic Details
Published inFukuoka igaku zasshi = Hukuoka acta medica Vol. 104; no. 4; p. 136
Main Authors Tobiishi, Kazuhiro, Suzuki, Shigeru, Todaka, Takashi, Hirakawa, Hironori, Hori, Tsuguhide, Kajiwara, Jumboku, Hirata, Teruaki, Iida, Takao, Uchi, Hiroshi, Furue, Masutaka
Format Journal Article
LanguageEnglish
Published Japan 25.04.2013
Subjects
Humans
Hydroxylation
Japan
Polychlorinated Biphenyls - blood
Porphyrias - blood
Japan
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Summary:Hydroxylated polychlorinated biphenyls (OH-PCBs) are formed as major metabolites of PCBs by cytochrome P450 enzyme-mediated oxidation. It has been reported that their total concentration in serum samples of Yusho patients ranged from 390 to 1300 pg/g. We measured the concentration of OH-PCBs in blood collected from 183 Yusho patients living in Japan in 2010. The major OH-PCB metabolites were 4-OH-CB187 (ND-1300 pg/g-wet), 4-OH-CB146 + 3-OH-CB153 (8.4-1200 pg/g-wet), 4-OH-CB109 (ND-530 pg/g-wet) and 4'-OH-CB172 (ND-380 pg/g-wet). The total OH-PCBs ranged from 36 to 3800 pg/g-wet. A positive relationship between the concentrations of OH-PCBs and PCBs was observed, but no significant relationship between the concentrations of OH-PCBs and PCDD/DFs was observed.
ISSN:0016-254X