CHANGES OF DIALYSIS EFFICIENCY BY IMPROVEMENT OF RENAL ANEMIA DURING ERYTHROPOIETIN THERAPY

• Published in: Jinko Zoki Vol. 20; no. 1; pp. 19 - 22
• Main Authors: ICHIKAWA, H., YAMAZAKI, H., TAKEDA, F., MOMOSE, T., KOIDE, K., KAWASAKI, T., SANO, M.
• Format: Journal Article
• Language: Japanese
• Published: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS 1991; 一般社団法人 日本人工臓器学会
• Subjects: Dialysis Efficiency; Erythropoietin Therapy; Reduction Rates; Renal Anemia
• ISSN: 0300-0818; 1883-6097
• DOI: 10.11392/jsao1972.20.19

While the renal anemia is remarkably improved by rHuEPO administration, there is possibility of the decrease of dialysis efficiency by an increase of Ht. We studied the changes of reduction rates of scfutes with the stable maintenance hemodialysis (HD) patients before and after the rHuEPO administration The subjects are the 8 patients with an improvement in anemia by rHuEPO therapy and at the same time with no changes in HD conditions such as QB, dialysers and dialysis time, The duration of the study was in tota16 months including 3 months before rHuEPO therapy and the 3 months during which Ht was consecutively more than 30% by the rHuEPO therapy. The increase of Ht was 9, 65±2.45% in avarageo As for the changes of reduction rate of solutes UN, P and uremic toxin peak 2a showed no notable changes, though Cr and UA showed a remarkable decrease. There was no case in which the HD condition had to be changed because of the decrease of dialysis efficiency of Cr and UA. Therefore, there seems to be no clinical problems as long as Ht is kept in 30%.