EFFECT OF CEFAMANDOLE ON THE FERTILITY AND REPRODUCTION OF RATS

• Published in: CHEMOTHERAPY Vol. 27; no. Supplement5; pp. 649 - 657
• Main Authors: SASAKI, KAZUNORI, KOBAYASHI, FUMIHIKO
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Chemotherapy 1979
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.27.Supplement5_649

Cefamandole at doses of 500, 1, 000 or 2, 000mg/kg, was administered intraperitoneally to male rats for 9 weeks and to female rats for 14 days prior to mating. The administration regimens were continued for the males and females during cohabitation for mating and for the females during early pregnancy until Day 7 of gestation. All females were necropsied for cesarean section on Day 21 of gestation. All rats survived during the study. Slight but significant inhibition of growth was observed in only the male rats given the compound. No parental toxicity was apparent in the fertility and reproduction phases of the study. Fetal parameters, i.e. morphological development, viability, weight and sex distribution were unaffected by the treatment. No defects were observed for visceral and skeletal specimens of the progeny. Cefamandole at doses as great as 2, 000 mg/kg, was without effect on the reproductive performance of the rats, and all progeny appeared normal.