LABORATORY AND CLINICAL EVALUATION OF CEFACLOR

• Published in: CHEMOTHERAPY Vol. 27; no. Supplement7; pp. 487 - 494
• Main Authors: YAMADA, YOSHINARI, SAITO, TOSHIAKI
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1979
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.27.Supplement7_487

Laboratory and clinical studies were conducted on cefaclor (CCL). The in vitro antibacterial activity of CCL and cefalexin (CEX) against 40 clinical isolats of Staphylococcus aureus and Escherichia coli was compared. The inoculum sizes were 108 and 106 cells/ml. Especially CCL appears to be more active on the 106 cells/ml than CEX against both strains. CCL inhibited 60% of Escherichia coli at 1.56μg/ml and 95% at 3.13μg/ml. To achieve similar levels of activity, 12.5μg/ml of CEX was required. Against Staphylococcus aureus, 1.56μg/ml and 3.13μg/ml of CCL inhibited 55% and 80% of the strains. To achieve the same levels of activity, 6.25μg/ml of CEX was needed.(The results mentioned above were obtained from the condition of inoculum size of 106 cells/ml). One of the 23 cases treatment was unachieveable because of nausea. The treatment was successful in 16 patients out of 22 patients.