CLINICAL EXPERIENCE OF NETILMICIN USED FOR CHRONIC COMPLICATED URINARY TRACT INFECTIONS

• Published in: CHEMOTHERAPY Vol. 29; no. Supplement3; pp. 496 - 508
• Main Authors: UEDA, SATORU, UENO, FUMIMARO, IKEGAMI, KEIICHI
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1981
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.29.Supplement3_496

A daily dose 150 mg, or 200 mg, divided twice, of Netilmicin (NTL) was administered intramuscularly to 35 cases of chronic complicated urinary tract infections for 5 successive days, and the clinical and bacteriological effects were examined. By a daily dose of 150 mg, normalization or improvement of pyuria was seen in 43.8% of the patients, and bacteriuria became negative in 25%. Overall clinical effectiveness was shown in 50%. By a daily dose of 200 mg, normalization or improvement of pyuria was seen in 53.3% of the patients, and bacteriuria became negative in 40%. Overall clinical effectiveness was shown in 53.3%. The effectiveness classified by type of infection was not clarified because of insufficient numbers of cases. Pyuria was normalized or improved in 47.1% of catheterized cases, and bacteriuria became negative in 23.5% of these cases, and overall clinical efiectiveness was Zshown in 47.1% in catheterized cases. Clinical effects obtained by a daily dose of 150 mg and 200 mg were not significantly different. Bacteriological effect of netilmicin was as follows: Strains of Serratia marcescens, Proteus spp., E. coli, Klebsiella pneumoniae, or Streptococcus faecalis disappeared in higher percentage after netilmicin administration, but disappearance of Pseudomonas aeruginosa was lower. Disappearance of 87.5% of bacterial strains for less than 100μg/ml netilmicin sensitivity and of 50.0% for more than 100μg/ml was observed. Angular stomatitis, 1 case, and pain and induration at the injection site were observed, but the relation to netilmicin injection was not clarified. No other adverse effect was observed. As shown above, netilmicin, one of aminoglycoside antibiotics, may be claimed to be a relatively safe therapeutic agent for the treatment of chronic complicated infection of the urinary tract.