TOXICITY STUDY ON AZTHREONAM (6) PERINATAL AND POSTNATAL STUDY IN RATS

• Published in: CHEMOTHERAPY Vol. 33; no. Supplement1; pp. 219 - 231
• Main Authors: FURUHASHI, TADAKAZU, USHIDA, KAZUO, TAKEI, AKIKO, NAKAYOSHI, HIROSHI
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1985
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.33.Supplement1_219

Perinatal and postnatal study on Azthreonam (AZT), a newly developed monobactam antibiotic, was conducted by intravenous injection in Sprague-Dawley rats. AZT was administered to female rats from day 17 of gestation throughout day 20 after delivery. Body weight gain was decreased from day 14 of lactation until weaning in dams (270mg/kg or more). Food intake showed a transient decrease after administration (100mg/kg or more) and an increase after delivery (750mg/kg). Water intake increased after administration (270mg/kg or more). An animal in the 750mg/kg group showed a delayed delivery and died on day 23 of gestation. This animal presented vacuolation of hepatocytes and tubular epithelium. At necropsy on day 21 of lactation, the increase in weight of caecum (all administration groups) was observed. No changes were observed as to live birth index, viability index, weaning index, sex ratio, body weight, postnatal physical developments, external, visceral and skeletal malformations, organ weights at the age of 21 and 84 days, functional developments, behavioral developments, emotional activity, learning ability and reproductive performance. Thus, the maximum no-effect dose level of AZT in the next generation in the present study, was estimated to be 750mg/kg.