BASIC AND CLINICAL STUDIES ON CEFOPERAZONE (T-1551)

Cefoperazone (CPZ, T-1551), a new cephalosporin antibiotic, was studied fundamentally and clinically, and the following results were obtained. CPZ was compared with cefazolin and piperacillin in antibacterial activity against gram-negative bacilli and gram-positive cocci isolated from clinical mater...

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Published inCHEMOTHERAPY Vol. 28; no. Supplement6; pp. 569 - 574
Main Authors TOKUNAGA, KATSUMASA, SHIMA, KIYOSHI, FUKUDA, YASUTSUGU, HAMADA, KAZUHIRO, TOKUOMI, HARUHIKO
Format Journal Article
LanguageEnglish
Japanese
Published Japanese Society of Chemotherapy 1980
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Summary:Cefoperazone (CPZ, T-1551), a new cephalosporin antibiotic, was studied fundamentally and clinically, and the following results were obtained. CPZ was compared with cefazolin and piperacillin in antibacterial activity against gram-negative bacilli and gram-positive cocci isolated from clinical materials. Against gram-negative bacilli CPZ was the most active than cefazolin. Against Pseudomonas and S. marcescens CPZ showed equal activity to piperacillin. As the result of CPZ treatment, CPZ was effective in all 11 cases (8 with respiratory tract infection, 1 with biliary tract infection and 2 with urinary tract infection). No side effects were observed with CPZ in hemogram, liver function, kidney functinn and others.
ISSN:0009-3165
1884-5894
DOI:10.11250/chemotherapy1953.28.Supplement6_569