LABORATORY AND CLINICAL STUDIES OF CEFADROXIL IN OPHTHALMOLOGIC FIELD

• Published in: CHEMOTHERAPY Vol. 28; no. Supplement2; pp. 499 - 505
• Main Authors: OISHI, MASAO, NISHIZUKA, KENJI, MOTOYAMA, MARIKO, OGAWA, TAKESHI, NAGAI, SHIGEO
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1980
• DOI: 10.11250/chemotherapy1953.28.Supplement2_499
• ISSN: 0009-3165

Cefadroxil, a new cephalosporin antibiotic, has an antibacterial activity similar to that of cephalexin (CEX). Sensitivity of 15 strains of Staph. aureus isolated clinically was distributed between 1.56-6.25μg/ml, and the peak of 3.13μg/ml was noticed in 8 strains (53.3%). Three healthy volunteers were administered orally 500mg of the agent at fasting early in the morning, and the average peak value of 12.93μg/ml was obtained after 2 hours, then decreasing gradually, the average level was 2.16μg/ml after 6 hours. Intraocular penetration was determined in white mature rabbit. A dose of 50mg/kg was administered orally, and the peak value in aqueous humor was 1.73μg/ml after 2 hours, aqueous humor/serum ratio being 20.11%. The ocular tissue levels were transferred well too in outer and inner parts of the eyes after 2 hours. A dose of 250mg or 500mg of the agent was administered clinically per os 3 times per day in 20 cases of various bacterial infections of eye, and the result obtained was excellent in 3 cases, good in 11 cases, fair in 4 cases, poor in 1 case, and unknown in 1 case. As to the side effect of the agent, 1 case complained of diarrheic symptoms, and the administration was interrupted. No other effects as allergic reaction were observed.