LABORATORY AND CLINICAL STUDIES OF CEFADROXIL IN OPHTHALMOLOGIC FIELD
Cefadroxil, a new cephalosporin antibiotic, has an antibacterial activity similar to that of cephalexin (CEX). Sensitivity of 15 strains of Staph. aureus isolated clinically was distributed between 1.56-6.25μg/ml, and the peak of 3.13μg/ml was noticed in 8 strains (53.3%). Three healthy volunteers w...
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Published in | CHEMOTHERAPY Vol. 28; no. Supplement2; pp. 499 - 505 |
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Main Authors | , , , , |
Format | Journal Article |
Language | Japanese |
Published |
Japanese Society of Chemotherapy
1980
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Online Access | Get full text |
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Summary: | Cefadroxil, a new cephalosporin antibiotic, has an antibacterial activity similar to that of cephalexin (CEX). Sensitivity of 15 strains of Staph. aureus isolated clinically was distributed between 1.56-6.25μg/ml, and the peak of 3.13μg/ml was noticed in 8 strains (53.3%). Three healthy volunteers were administered orally 500mg of the agent at fasting early in the morning, and the average peak value of 12.93μg/ml was obtained after 2 hours, then decreasing gradually, the average level was 2.16μg/ml after 6 hours. Intraocular penetration was determined in white mature rabbit. A dose of 50mg/kg was administered orally, and the peak value in aqueous humor was 1.73μg/ml after 2 hours, aqueous humor/serum ratio being 20.11%. The ocular tissue levels were transferred well too in outer and inner parts of the eyes after 2 hours. A dose of 250mg or 500mg of the agent was administered clinically per os 3 times per day in 20 cases of various bacterial infections of eye, and the result obtained was excellent in 3 cases, good in 11 cases, fair in 4 cases, poor in 1 case, and unknown in 1 case. As to the side effect of the agent, 1 case complained of diarrheic symptoms, and the administration was interrupted. No other effects as allergic reaction were observed. |
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ISSN: | 0009-3165 1884-5894 |
DOI: | 10.11250/chemotherapy1953.28.Supplement2_499 |