STUDIES ON KW-1070 IN COMPLICATED URINARY TRACT INFECTIONS

1) Bacterial activity Minimal inhibitory concentrations of KW-1070, GM, AMK and netilmicin were determined by plate dilution method against Serratia marcescens (82strains) isolated from urinary tract infection. The MIC value of KW-1070 ranged from 1.56μg/ml to 12.5μg/ml. These values were similar to...

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Published inCHEMOTHERAPY Vol. 29; no. Supplement2; pp. 582 - 589
Main Authors FUJIMURA, NOBUO, YONEDA, FUMIO, TATARA, KIYOSHI, TANAKA, TOSHIHIRO, KUROKAWA, KAZUO
Format Journal Article
LanguageEnglish
Japanese
Published Japanese Society of Chemotherapy 1981
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Abstract 1) Bacterial activity Minimal inhibitory concentrations of KW-1070, GM, AMK and netilmicin were determined by plate dilution method against Serratia marcescens (82strains) isolated from urinary tract infection. The MIC value of KW-1070 ranged from 1.56μg/ml to 12.5μg/ml. These values were similar to those of GM whereas even better than those of AMK and netilmicin. 2) Clinical trials Thirty-one patients suffering from complicated urinary tract infection (18 upper UTI and 13 lower UTI) were trieated with KW-1070. KW-1070 was administrated 400mg, 600mg or 800mg daily by intramuscular injection for 5 days. The results were excellent in 5 cases, moderate in 18 cases, poor in 8 cases and the rate of effectiveness was 74.2%. Bacteriological outcome was as follows: eradicated in 28 strains (71.8%), persisted in 11 strains (28.2%) out of 39 strains isolated. No serious side effects were observed. Temporal election of S-GOT, S-GPT in 1 cases and SGOT, S-GPT, Al-P in 2 case were observed, but these elevation decreased after 7 days of final adminisreation of KW-1070.
AbstractList 1) Bacterial activity Minimal inhibitory concentrations of KW-1070, GM, AMK and netilmicin were determined by plate dilution method against Serratia marcescens (82strains) isolated from urinary tract infection. The MIC value of KW-1070 ranged from 1.56μg/ml to 12.5μg/ml. These values were similar to those of GM whereas even better than those of AMK and netilmicin. 2) Clinical trials Thirty-one patients suffering from complicated urinary tract infection (18 upper UTI and 13 lower UTI) were trieated with KW-1070. KW-1070 was administrated 400mg, 600mg or 800mg daily by intramuscular injection for 5 days. The results were excellent in 5 cases, moderate in 18 cases, poor in 8 cases and the rate of effectiveness was 74.2%. Bacteriological outcome was as follows: eradicated in 28 strains (71.8%), persisted in 11 strains (28.2%) out of 39 strains isolated. No serious side effects were observed. Temporal election of S-GOT, S-GPT in 1 cases and SGOT, S-GPT, Al-P in 2 case were observed, but these elevation decreased after 7 days of final adminisreation of KW-1070.
Author TANAKA, TOSHIHIRO
TATARA, KIYOSHI
YONEDA, FUMIO
KUROKAWA, KAZUO
FUJIMURA, NOBUO
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  fullname: KUROKAWA, KAZUO
  organization: Department of Urology, Shool of Medicine, Tokushima University
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References 2) EGAN, R. S.; R. S. STANAZEK, M. CLROVIC, S. L. MUELLER, J. TADANIER, J. R. MARTIN, P. COLLUM, A. W. GOLDSTEIN, R. L. DE VAULT, A. C. SINCLAIR, E. E. FAGER & L. A. MITSCHER: Fortimicins A and B, new aminoglycoside antibiotics. III. Structural identification. J. Antibiotics 30: 552-563, 1977
5) 日本化学療法学会MIC小委員会: 最小発育阻止濃度 (MIC) 測定法改正について. Chemotherapy22: 1126-1128, 1974
6) 第28回日本化学水法学会総会, 新薬シンポジウム1, KW-1070, 1980
3) GIROLAMI, R. L. & J. M. STAMM: Fortimicins A and B, new aminoglycoside antibiotics. IV. In vitro study of fortimicin A compared with other aminoglycosides. J. Antibiotics 30: 564-570, 1977
4) OHASHI, Y.; H. KAWABE, K. SATO, N. NAKAMURA, S. KURASHIGE & S. MITSUHASITI: Fortimicin A, a new aminoglycoside antibiotic; In Microbial Drug Resistance II; S. MITSUHASHI (ed.) Japan Scientific Societies Press, Univ. Park Press, Tokyo and Baltimore, 263-267, 1979
1) NARA, T.; M. YAMAMOTO, I. KAWAMOTO, K. TAKAYAMA, R. OKACHI, S. TAKASAWA, T. SATO & S. SATO: Fortimicins A and B, new aminoglycoside antibiotics. I. Producing organism, fermentation and biological properties of fortimicins. J. Antibiotics 30: 533-540 1977
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Snippet 1) Bacterial activity Minimal inhibitory concentrations of KW-1070, GM, AMK and netilmicin were determined by plate dilution method against Serratia marcescens...
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Title STUDIES ON KW-1070 IN COMPLICATED URINARY TRACT INFECTIONS
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