STUDIES ON KW-1070 IN COMPLICATED URINARY TRACT INFECTIONS

• Published in: CHEMOTHERAPY Vol. 29; no. Supplement2; pp. 582 - 589
• Main Authors: FUJIMURA, NOBUO, YONEDA, FUMIO, TATARA, KIYOSHI, TANAKA, TOSHIHIRO, KUROKAWA, KAZUO
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Chemotherapy 1981
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.29.Supplement2_582

1) Bacterial activity Minimal inhibitory concentrations of KW-1070, GM, AMK and netilmicin were determined by plate dilution method against Serratia marcescens (82strains) isolated from urinary tract infection. The MIC value of KW-1070 ranged from 1.56μg/ml to 12.5μg/ml. These values were similar to those of GM whereas even better than those of AMK and netilmicin. 2) Clinical trials Thirty-one patients suffering from complicated urinary tract infection (18 upper UTI and 13 lower UTI) were trieated with KW-1070. KW-1070 was administrated 400mg, 600mg or 800mg daily by intramuscular injection for 5 days. The results were excellent in 5 cases, moderate in 18 cases, poor in 8 cases and the rate of effectiveness was 74.2%. Bacteriological outcome was as follows: eradicated in 28 strains (71.8%), persisted in 11 strains (28.2%) out of 39 strains isolated. No serious side effects were observed. Temporal election of S-GOT, S-GPT in 1 cases and SGOT, S-GPT, Al-P in 2 case were observed, but these elevation decreased after 7 days of final adminisreation of KW-1070.