Activity of teicoplanin, a new glycopeptide, against anaerobic bacteria

The in vitro activity of teicoplanin (TEIC), a new glycopeptide, was studied in a variety of anaerobic bacteria. TEIC was more active than vancomycin (VCM) against gram-positive cocci including Peptostreptococcus spp., Clostridium spp., and Gardnerella vaginalis, a fastidious facultative anaerobe, a...

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Bibliographic Details
Published inCHEMOTHERAPY Vol. 41; no. Supplement2; pp. 56 - 61
Main Authors Kato, Naoki, Kato, Haru, Tanaka, Yasunori, Tanaka, Kaori, Watanabe, Kunitomo, Ueno, Kazue
Format Journal Article
LanguageJapanese
Published Japanese Society of Chemotherapy 1993
Subjects
Bacteroides fragilis
glycopeptide
Teicoplanin
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Summary:The in vitro activity of teicoplanin (TEIC), a new glycopeptide, was studied in a variety of anaerobic bacteria. TEIC was more active than vancomycin (VCM) against gram-positive cocci including Peptostreptococcus spp., Clostridium spp., and Gardnerella vaginalis, a fastidious facultative anaerobe, and comparable to VCM against Mobiluncus spp. Among gram-negative rods, although TEIC had little activity against Bacteroides spp. including Bacteroides fragilis group organisms, this compound was active against Prevotella spp. that were not susceptible to VCM. In addition, TEIC was more active than VCM against Porphyromonas spp. TEIC had little activity against Lactobacillus spp., of a major member of the intestinal flora, as did VCM.
ISSN:0009-3165
1884-5894
DOI:10.11250/chemotherapy1953.41.Supplement2_56