IN VIVO ANTIBACTERIAL ACTIVITY OF CEFMENOXIME (SCE-1365) AGAINST ANAEROBES

The therapeutic efficacy of cefmenoxime (CMX, SCE-1365) against experimental anaerobic infections in mice was compared with those of cefazolin, 6059-S and ceftizoxime. 1. Cefmenoxime showed more potent therapeutic effect than cefazolin against experimental mixed infections with Escherichia coli and...

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Published inCHEMOTHERAPY Vol. 29; no. Supplement1; pp. 53 - 56
Main Authors KOBAYASHI, TOYOKO, ISONO, MIDORI, AOKI, MAKOTO, UMEMURA, ATSUSHI, MARUI, TOSHINORI, WATANABE, KUNITOMO, UENO, KAZUE
Format Journal Article
LanguageJapanese
Published Japanese Society of Chemotherapy 1981
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Summary:The therapeutic efficacy of cefmenoxime (CMX, SCE-1365) against experimental anaerobic infections in mice was compared with those of cefazolin, 6059-S and ceftizoxime. 1. Cefmenoxime showed more potent therapeutic effect than cefazolin against experimental mixed infections with Escherichia coli and Bacteroidcs fragilis β-lactamase producing. 2. Cefmenoxime exhibited significant bactericidal effects judging from the growth curves in mice spleen of B. fragilis. 3. Cefmenoxime showed excellent in vivo activity against experimental infection with B. fragilis in mice.
ISSN:0009-3165
1884-5894
DOI:10.11250/chemotherapy1953.29.Supplement1_53