Rhodium-catalyzed asymmetric addition of arylboronic acids to 2H-chromenes leading to 3-arylchromane derivatives

Asymmetric addition of arylboronic acids to 2H-chromenes proceeded in the presence of a hydroxorhodium/chiral diene catalyst to give 3-arylchromanes in high yields with high enantioselectivity. The reaction involves 1,4-Rh shift before protonation to release the addition product and to regenerate th...

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Published inChemical communications (Cambridge, England) Vol. 55; no. 79; pp. 11876 - 11879
Main Authors Umeda, Moeko, Sakamoto, Kana, Nagai, Tomotaka, Nagamoto, Midori, Ebe, Yusuke, Nishimura, Takahiro
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2019
Royal Society of Chemistry
Subjects
Asymmetry
Catalysis
Chemistry
Chemistry, Multidisciplinary
Enantiomers
Physical Sciences
Protonation
Rhodium
Science & Technology
EQUOL
1,4-ADDITION
LIGAND
C-60
ALKYNES
C/C-H ACTIVATION
HYDROARYLATION
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Summary:Asymmetric addition of arylboronic acids to 2H-chromenes proceeded in the presence of a hydroxorhodium/chiral diene catalyst to give 3-arylchromanes in high yields with high enantioselectivity. The reaction involves 1,4-Rh shift before protonation to release the addition product and to regenerate the hydroxorhodium species.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc06221a