Spinal cord regeneration and functional recovery: neurotransmitter's combination and bone marrow cells supplementation

• Published in: Current science (Bangalore) Vol. 97; no. 4; pp. 546 - 549
• Main Authors: Paulose, C. S., John, P. S., Sreekanth, R., Philip, Mathew, Mohan, C. Padmarag, Mathew, Jobin, Kumar, T. Peeyush, Paul, Jes, Abraham, Pretty Mary, Antony, Sherin, Joseph, Binoy, Joseph, Anu, Krishnakumar, Amee, Anju, T. R., Khan, S. Reas, Thomas, K. Santhosh, Nandhu, M. S.
• Format: Journal Article
• Language: English
• Published: Current Science Association 25.08.2009
• Subjects: Bone marrow; Bone marrow cells; Cell growth; Central nervous system; Hepatocytes; Neurons; Physical trauma; Receptors; RESEARCH COMMUNICATIONS; Spinal cord; Stem cells
• ISSN: 0011-3891

We report here the regenerative cell proliferation and functional recovery of spinal cord injury after supplementation with neurotransmitter's combination and bone marrow cells. Monoplegia was induced in male Wistar rats by producing a wound between 12th and 13th vertebra and they were treated with neurotransmitter's combination and bone marrow cells for 21 days. GABA and 5HT receptors were down-regulated in the spinal cord of the injured rats and the treatment reversed the parameters to near control. Nuclear staining and reward seeking locomotor test support spinal cord regeneration. Our results suggest the neurotransmitter's combination with the bone marrow cells as a successful treatment for re-establishing the connections and functional recovery of spinal cord injury.