ANTI-PROLIFERATIVE ACTIVITIES OF 32 MALAYSIAN PLANT SPECIES IN BREAST CANCER CELL LINES

Anti-proliferative activities of 143 crude extracts obtained from 32 plants collected from the rain forests of Pahang, Malaysia, were evaluated in two breast cancer cell lines, i.e. MCF-7 and T47D, obtained from the American Type Culture Collection, USA. The objective of this study was to bioprospec...

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Bibliographic Details
Published inJournal of tropical forest science Vol. 20; no. 2; pp. 77 - 81
Main Authors Nurhanan, M. Y., Asiah, O., Ilham, M. A. Mohd, Syarifah, M. M. Siti, Norhayati, I., Sahira, H. Lili
Format Journal Article
LanguageEnglish
Published Kuala Lumpur Forest Research Institute Malaysia 01.04.2008
Subjects
Antineoplastics
Breast cancer
Cell lines
Chemotherapy
Ethanol
Inhibitory concentration 50
Plant anatomy
Plants
Tropical forests
Tropical rain forests
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Summary:Anti-proliferative activities of 143 crude extracts obtained from 32 plants collected from the rain forests of Pahang, Malaysia, were evaluated in two breast cancer cell lines, i.e. MCF-7 and T47D, obtained from the American Type Culture Collection, USA. The objective of this study was to bioprospect a list of plants to find out their potential to be developed into anti-cancer drug(s), by means of bioassay guided isolation procedure. After performing sulforhodamine-B assay, 13 crude extracts from 11 plant species were found to have active anti-proliferative effects (IC50 ≤ 100 μg ml-1). Aktiviti anti-proliferasi 143 ekstrak mentah daripada 32 tumbuhan yang diperoleh daripada hutan hujan Pahang, Malaysia dikaji terhadap dua jenis sel kanser buah dada iaitu MCF-7 dan T47D yang diperoleh daripada Koleksi Kultur Tip Amerika, Amerika Syarikat. Kajian ini menjalankan bioprospek terhadap tumbuhan bagi menilai potensi mereka untuk dibangunkan menjadi ubat anti-kanser menggunakan kaedah pengasingan biocerakinan. Selepas cerakinan sulforhodamina-B, 13 ekstrak mentah daripada 11 spesies tumbuhan dikenal pasti mempunyai kesan anti-proliferasi yang aktif (IC50 ≤ 100 μg ml-1).
ISSN:0128-1283
2521-9847