Action de la Mitomycine C sur l'Ultrastructure de Chromosomes Metaphasiques Lymphocytaires Humains

Mitomycine at high concentrations cause the splitting of the lymphocytic nuclei and inhibits the formation of the mitotic metaphase plates; at average concentrations and under the chosen conditions of experimentation, it determines various chromosomal abnormalities: stretchings, constrictions of the...

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Bibliographic Details
Published inCYTOLOGIA Vol. 49; no. 4; pp. 703 - 708
Main Authors Turchini, Marie-France, Mathe, O., Jaffray, J. Y., Malet, P., Turchini, Jean-Pascal
Format Journal Article
LanguageEnglish
Published Tokyo Japan Mendel Society, International Society of Cytology 1984
Japan Science and Technology Agency
Subjects
aberrations
C-Cultures-Chromosomes-Ultrastructural
Mitomycine
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Summary:Mitomycine at high concentrations cause the splitting of the lymphocytic nuclei and inhibits the formation of the mitotic metaphase plates; at average concentrations and under the chosen conditions of experimentation, it determines various chromosomal abnormalities: stretchings, constrictions of the chromatides and even ruptures. The constrictions observed have an arrangement comparable to band systems, but without precise correspondence with the G and R labeling systems.
ISSN:0011-4545
1348-7019
DOI:10.1508/cytologia.49.703