Correlation between the pharyngeal secretion of IgA, secretory-IgA and free secretory component and the upper respiratory tract infections in patients with IgA nephorpathy

The levels of IgA, secretory-IgA (s-IgA) and free secretory component (FSC) in pharyngeal washings were examined in patients with IgA nephropathy, other glomerular diseases and healthy adults. The levels of IgA or s-IgA in the pharyngeal washings were significantly increased in patients with IgA nep...

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Published inThe Japanese Journal of Nephrology Vol. 29; no. 9; pp. 1101 - 1105
Main Authors YAGAME, MITSUNORI, TOMINO, YASUHIKO, EGUCHI, KAZUHIKO, MIYAZAKI, MASANOBU, MIURA, MASAHIKO, SUGA, TAKAO, ENDOH, MASAYUKI, NOMOTO, YASUO, SAKAI, HIDETO
Format Journal Article
LanguageEnglish
Published Japanese Society of Nephrology 1987
Subjects
FSC
IgA
IgA nephropathy
pharyngeal washings
s-IgA
upper respiratory tract infections
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Summary:The levels of IgA, secretory-IgA (s-IgA) and free secretory component (FSC) in pharyngeal washings were examined in patients with IgA nephropathy, other glomerular diseases and healthy adults. The levels of IgA or s-IgA in the pharyngeal washings were significantly increased in patients with IgA nephropathy or other glomerular diseases as compared to those in healthy adults. There was a significant correlation between the levels of s-IgA and those of IgA and FSC in the pharyngeal washings from patients with IgA nephropathy. Infections of the upper respiratory tract within one year prior to the present study were more frequent in patients with IgA nephropathy than in those with other glomerular diseases. It is suggested that the mucosal resposise of the upper respiratory tract may be hyperreactive in patients with IgA nephropathy.
ISSN:0385-2385
1884-0728
DOI:10.14842/jpnjnephrol1959.29.1101