N-Monomethylation of amines using paraformaldehyde and H2

The selective N-monomethylation of amines is an important topic in fine chemical synthesis. Herein, for the first time, we described a selective N-monomethylation reaction of amines with paraformaldehyde and H2 in the presence of a CuAlOx catalyst. A variety of amines, including primary aromatic ami...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 53; no. 40; pp. 5542 - 5545
Main Authors Wang, Hongli, Huang, Yongji, Dai, Xingchao, Shi, Feng
Format Journal Article
LanguageEnglish
Published 2017
Subjects
Amines
Catalysts
Compatibility
Fine chemicals
Synthesis (chemistry)
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Summary:The selective N-monomethylation of amines is an important topic in fine chemical synthesis. Herein, for the first time, we described a selective N-monomethylation reaction of amines with paraformaldehyde and H2 in the presence of a CuAlOx catalyst. A variety of amines, including primary aromatic amines, benzylamine and cyclohexylamine, as well as secondary amines, have been shown to be compatible with this reaction.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc02314f