Studies on Hyaluronidase Inhibitor of Gymnema sylvestre R. Br

The inhibitory activity of hyaluronidase was found in the water extract of Gymnema sylvestre. The two active compounds were purified with gel filtration, followed by anion exchange chromatography, and their structural study were performed by GC-MS and carbazole method. On the bases of these results,...

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Published inEisei kagaku Vol. 36; no. 4; pp. 314 - 319
Main Authors SAWABE, YOSHIYUKI, IWAGAMI, SHOZO, MAEDA, YUMIE, NAKAGOMI, KAZUYA, SUZUKI, SUMIKO, NAKAZAWA, HIROYUKI
Format Journal Article
LanguageJapanese
Published The Pharmaceutical Society of Japan 31.08.1990
Subjects
D-galacturonic acid
Gymnema sylvestre
hyaluronidase inhibitor
pectic substance
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Summary:The inhibitory activity of hyaluronidase was found in the water extract of Gymnema sylvestre. The two active compounds were purified with gel filtration, followed by anion exchange chromatography, and their structural study were performed by GC-MS and carbazole method. On the bases of these results, the two active substances were proved to be pectic substances containing 73% D-galacturonic acid with approximately 4.0×104 and 2.0×104 of molecular weight as I and II, respectively.
ISSN:0013-273X
DOI:10.1248/jhs1956.36.314