URINARY 17-HYDROXYCORTICOSTEROIDS, 17-KETOSTEROIDS, PREGNANEDIOL AND PREGNANETRIOL IN PATIENTS WITH MYASTHENIA GRAVIS

Urinary steroids in 13 patients with myasthenia gravis were analytically examined in order to investigate whether or not any endocrinological disturbances existed in myasthenic patients. Urinary excretion of 17-OHCS, 17-KS and pregnanediol, and the recovery of injected progesterone estimated as preg...

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Published inEndocrinologia Japonica Vol. 11; no. 3; pp. 237 - 244
Main Authors TAKEDA, YOSHIAKI, YOSHIDA, SHIZUO, UOZUMI, TOHRU, NOZAKI, RYOICHI, KAJIMURA, MUNEO, MATSUMOTO, KEISHI, SEKI, TOKUICHIRO
Format Journal Article
LanguageEnglish
Published The Japan Endocrine Society 1964
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Summary:Urinary steroids in 13 patients with myasthenia gravis were analytically examined in order to investigate whether or not any endocrinological disturbances existed in myasthenic patients. Urinary excretion of 17-OHCS, 17-KS and pregnanediol, and the recovery of injected progesterone estimated as pregnanediol were normal in almost all cases examined before and after thymectomy. The hydroxylation of the position 21 and 11 of the steroid ring were considered to be within normal range. Although some definite changes in the ratios of 5β-H-steroids to 5α-H-steroids were found (before and after thymectomy), further studies on othersurgical operations would be necessary to decide whether or not such changes arespecific to thymectomy in myasthenic patients.
ISSN:0013-7219
2185-6370
DOI:10.1507/endocrj1954.11.237