A case of anti-MOG antibody-positive multiphasic disseminated encephalomyelitis co-occurring with unilateral cerebral cortical encephalitis

A 20-year-old woman first developed acute disseminated encephalomyelitis (ADEM) at 11 years of age. At 17 years of age, she was hospitalized due to generalized seizure and diagnosed with encephalitis. Brain MRI revealed a FLAIR-hyperintense lesion in the unilateral cerebral cortex. At 18 years of ag...

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Bibliographic Details
Published inRinsho Shinkeigaku Vol. 57; no. 11; pp. 723 - 728
Main Authors Fukushima, Naoya, Suzuki, Miki, Ogawa, Ryo, Hayashi, Kitami, Takanashi, Jun-ichi, Ohashi, Takashi
Format Journal Article
LanguageJapanese
Published Japan Societas Neurologica Japonica 25.11.2017
Subjects
anti-MOG antibody
Autoantibodies - blood
Biomarkers - blood
Cerebral Cortex
encephalitis
Encephalitis - complications
Encephalitis - diagnosis
Encephalitis - immunology
Encephalomyelitis, Acute Disseminated - complications
Encephalomyelitis, Acute Disseminated - diagnosis
Encephalomyelitis, Acute Disseminated - immunology
epileptic seizure
Female
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
multiphasic disseminated encephalomyelitis
Myelin-Oligodendrocyte Glycoprotein - immunology
Neuroimaging
Young Adult
multiphasic disseminated encephalomyelitis
epileptic seizure
magnetic resonance spectroscopy
encephalitis
anti-MOG antibody
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Summary:A 20-year-old woman first developed acute disseminated encephalomyelitis (ADEM) at 11 years of age. At 17 years of age, she was hospitalized due to generalized seizure and diagnosed with encephalitis. Brain MRI revealed a FLAIR-hyperintense lesion in the unilateral cerebral cortex. At 18 years of age, serum anti-myelin oligodendrocyte glycoprotein (MOG) antibody was detected. At 20 years of age, she was admitted to our hospital, diagnosed with multifocal disseminated encephalomyelitis (MDEM). MDEM has been observed in patients that are seropositive for the anti-MOG antibody. More recently, unilateral cerebral cortex encephalitis with epilepsy has also been reported in such patients. The co-occurrence of MDEM and cortical encephalitis in the same patient has important implications for the pathogenesis of anti-MOG antibody-associated autoimmune diseases.
ISSN:0009-918X
1882-0654
DOI:10.5692/clinicalneurol.cn-001078