CLINICAL STUDIES ON FOSFOMYCIN IN INFLAMMATORY BILIARY DISEASES

• Published in: CHEMOTHERAPY Vol. 23; no. 5; pp. 1901 - 1906
• Main Authors: FURUSAWA, TEIJI, HISATSUGU, TAKEHARU, NAGANO, MASAO, KATO, HIDENORI, YAMAMOTO, HIROSHI, KONOMI, KOKI, NISHIMURA, MASAYA, KOIKE, MASAATSU, SAKAGUCHI, NOBUAKI, SHIMOMURA, TOHEI
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Chemotherapy 1975
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.23.1901

Eighteen patients with inflammatory biliary disease were treated orally with fosfomycin at dosag ranging from 2. 0 to 3.0g per day for periods ranging from 4 to 28 days. Four patients had cholecystolithiasis, three cholecystocholedocholithiasis, two choledocholithiasis, four hepatolithiasis, one cholangitis after choledochojejunostomy, two carcinoma of papilla duodeni, and two carcinoma of extrahepatic bile duct. Results were evaluated clinically as excellent in three cases, good in eight, fair in four, poor in two and unknown in one, and so an over-all efficacy was 61. 1%. No adverse side effects were found in either clinical signs or laboratory data, except a mild diarrhea occurring in a single patient. Fosfomycin susceptibility to 41 strains isolated from infected bile of patients with biliary diseases was measured by agar dilution technique. It was found that about 90% of isolates including Staphylococcus aureus, Staphylococcus epidermidis, E. coli, Enterobacter, Klebsiella, Pseudomonas aeruginosa, Citrobacter, Serratia and Bacterium anitratum was susceptible to the drug. The lowest MIC was found to be 0. 39, ug/m1 for a strain of Enterobacter and the highest >100 pg/ml for two strains of En-terobacter and a strain of Bacterium anitratum. The biliary excretion after single oral administration of 1 g of the drug was determined in two patients with common bile duct drainage. Biliary level of the drug in a patient was 1. 5, 1. 6 and 1. 6gglml at 6, 7 and 8 hours respectively. Recovery rates in urine for 8 hours in these two patients were 11. 2% and 6. 2% respectively.