Effects of Antiprostatic Agents on 5α-Dihydrotestosterone Binding to Rat Hypophyseal and Hypothalamic Cytosol Macromolecules

Tne binding of 5α-dihydrotestosterone to the hypophyseal and hypothalamic cytosol macromolecules prepared from castrated male rats was observed. The effects of antiprostatic agents on 5α-dihydrotestosterone binding to both hypophyseal and hypothalamic cytosol macromolecules was examined. Cyproterone...

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Published inEndocrinologia Japonica Vol. 26; no. 1; pp. 97 - 102
Main Authors YAMANAKA, HIDETOSHI, MATSUOKA, MASANORI, YUASA, HISAKO, KOYA, ATSUSHI, IMAI, KYOICHI, EBIHARA, KAZUNORI, NAKAI, KATSUKUKI, SHIDA, KEIZO
Format Journal Article
LanguageEnglish
Published The Japan Endocrine Society 1979
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Summary:Tne binding of 5α-dihydrotestosterone to the hypophyseal and hypothalamic cytosol macromolecules prepared from castrated male rats was observed. The effects of antiprostatic agents on 5α-dihydrotestosterone binding to both hypophyseal and hypothalamic cytosol macromolecules was examined. Cyproterone acetate and chlormadinone acetate Showed the significant inhibiting effects on 5α-dihydrotestosterone binding to 7-8 S macromolecules of cytosol from both hypophysis and hypothalamus. SCH 13521 and AA 560 did also affect 5α-dihydrotestosterone binding to 7-8 S macromolecules of cytosol from both tissues.
ISSN:0013-7219
2185-6370
DOI:10.1507/endocrj1954.26.97